ANXA1 and intracerebral hemorrhage: Activation of extracellular signal-regulated kinases 1/2 (ERK1/2) and ETS transcription factor ELK1 (Elk1) by ANXA1 can also promote granulocyte differentiation and maturation from hematopoietic stem cells [103], while ANXA1 induced p38 mitogen-activated protein kinase (p38 MAPK) activation attenuates neuroinflammation following intracerebral hemorrhage in mice [104].