The MSCs administrated intravenously decreased the number of Th2 cytokines such as IL-4, IL-5, IL-13, and IL-4-positive CD4+ T cells, but they increased the number of Th1 cytokine, IFN- γ and IFN- γ positive CD4+ T cells in the bronchoalveolar lavage (BAL) fluid and lung draining lymph nodes (LLNs) in an AR and asthma mouse model. This evidence concerns the gene IL4 and asthma.