Breast carcinoma cells treated with a combination of doxorubicin, cyclophosphamide, and cisplatin exhibited increased DNA damage when cultured in low glucose conditions and mice harboring ER+ breast tumors were more responsive to hormone therapy when fed a fasting mimicking diet (FMD) diet than when fed an ad libitum diet [170,171]. The gene discussed is ESR1; the disease is breast neoplasm.