Figure 6 and Figure S4 show that patients were more likely to report pruritus (OR = 1.84, 95% CI: 1.30–2.59) and rash (OR = 1.29, 95% CI: 1.08–1.55) in treatment arms compared with patients in the control arms. Figure S5 demonstrates that PD-L1 combined with chemotherapy groups were at increased risk of fever (OR = 2.04, 95% CI: 1.33–3.14) than the control group. The gene discussed is CD274; the disease is Pruritus.