CEP290 and Leber congenital amaurosis 10: The most common form of LCA, Leber congenital amaurosis type 10 (LCA10), is caused by loss-of-function mutations in the centrosomal protein 290 kDa (CEP290) gene, which encodes the protein necessary for the assembly of the connecting cilium of photoreceptors and phototransduction [173].