It has also been observed that GLI stability and nuclear localization is enhanced by Phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase (AKT) signaling in leukemia, esophageal adenocarcinoma, pancreatic cancer, melanoma, and MB [52,53,54,55,56,57]. The gene discussed is AKT1; the disease is melanoma.