Importantly, multiple BRD4 inhibitors including JQ1, I-BET151, CPI203, BMS-986158, MZ1, and ZEN-3365, have been shown to inhibit GLI-mediated transcription and the growth of GLI-dependent cancers ([66,67,68,69,70,71,118,128] and Table 2). This evidence concerns the gene GLI1 and cancer.