It is important not to lose the path given by antimicrobial stewardship and not to forget how antibiotics such as beta-lactams, once the mainstay of the treatment of infections, are now frequently vulnerable to inactivation by beta-lactamase—the same fate to which we condemned other classes of antibiotics that were once very effective, such as carbapenems now inactivated by carbapenemases. Here, LACTB is linked to infection.