The 2021 HF guidelines of the European Society of Cardiology (ESC) recommending the assessment of these molecules to rule out acute HF, at specific thresholds: <100 pg/mL for B-type natriuretic peptide (BNP) and 300 pg/mL for its N-terminal prohormone (NT-proBNP). The gene discussed is NPPB; the disease is hydrops fetalis.