PRLR and breast cancer: In order to locate the methylation sites of PRLR and CACNA2D1 in BC, we visualized the sites with MEXPRESS, and found that five methylation sites of PRLR were positively correlated with its expression, and seventeen sites bore negative correlation with its expression (Figure 8B), while sixteen methylation sites of CACNA2D1 were positively correlated with its expression, and twelve sites bore negative correlation with its expression (Figure 8C).