In this study, analyses on immune infiltration and immune checkpoints of CACNA2D1 found that CACNA2D1 was positively correlated with immune cells such as B cells, CD8+ T cells, CD4+ T cells, neutrophils, and dendritic cells, and the low CACNA2D1 expression in the immune cells was related to the poor prognosis of BC, suggesting that CACNA2D1 might impact the prognosis of BC patients by regulating the abundance of tumor immune cells. Here, CD4 is linked to neoplasm.