Programmed cell death 1 (PDCD1), programmed cell death 1 ligand 2 (PDCD1LG2), cytotoxic T-lymphocyte associated protein 4 (CTLA4), lymphocyte activating 3 (LAG3), hepatitis A virus cellular receptor 2 (HAVCR2), T cell immunoreceptor with Ig and ITIM domains (TIGIT), V-set immunoregulatory receptor (C10ORF54), and B and T lymphocyte associated (BTLA) are common immune checkpoints targeted by tumor immunity research. This evidence concerns the gene VSIR and neoplasm.