Prior studies found that CACNA2D1 played a certain role in the carcinogenesis of prostate cancer [45], bladder cancer [46], epithelial ovarian cancer [47], laryngeal squamous cell cancer [48], gastric cancer [49], non-small-cell cancer [50], and other cancers, but very few studies examined the association between CACNA2D1 and BC. Here, CACNA2D1 is linked to Familial prostate cancer.