Parameters such as Pulmonary Embolism Severity Index (PESI) and its simplified version (sPESI), thrombosis and cardiovascular biomarkers (NT-proBNP, Troponin, D-dimers) and echocardiographic markers of RV dysfunction (right ventricular diameter, tricuspid annular plane systolic elevation, systolic pulmonary artery pressure) have been presented in various studies and guidelines; however, none of them were able to specifically predict PE-related death [7,8,9]. Here, NPPB is linked to pulmonary embolism.