BRAF and melanoma: Furthermore, a recent case report of poly-neoplastic syndrome showed that in a patient with eight different cancers, five of them exhibited a BRAF V600E mutation (i.e., LCH, chronic lymphocytic leukemia, histiocytic sarcoma, melanoma, adenocarcinoma of the lung), in contrast to the other neoplasms (i.e., multiple myeloma, basal cell carcinoma, and papillary thyroid cancer).