Significant elevation in epithelial marker E-cadherin along with upregulated mesenchymal markers (N-Cadherin and vimentin), presenting a partial EMT behavior, suggested that STIM1 and Orai1 enhancement leads CSCs into the second phase (equilibrium) of the 3Es (elimination, equilibrium and escape) of the cancer immunoediting process, facilitating a shift from EMT to MET, depending on the microenvironment [52]. This evidence concerns the gene ORAI1 and cancer.