After finding high homology among Region 2 and certain parts of MPP7 and TGF β-LTBP, which are known to play a role in EMT, we tested the effects of STIM1 and/or Orai1 enhancement in Huh-7 HCC CSCs on “Epithelial to Mesenchymal Transition (EMT)” and “Mesenchymal to Epithelial Transition (MET)”. Here, MPP7 is linked to hepatocellular carcinoma.