In Huh-7 HCC cell lines, epithelial cell adhesion molecule (EpCAM)- and Prominin-1 (CD133)-co-expressing cell subpopulations were shown to possess stem cell-like properties, as they frequently caused tumor development in immunocompromised NOD/SCID mice xenograft models [4,5,6]. Here, PROM1 is linked to hepatocellular carcinoma.