Enhancement of endoplasmic reticulum (ER) transmembrane stromal interaction molecule 1 (STIM1) and/or Calcium Release-Activated Calcium Modulator 1 (Orai1) expression in Huh-7 CSCs increased store-operated Ca2+ entry (SOCE) and proliferation rate along with upregulated MDR1 expression, each associated with poor cancer prognosis [7]. This evidence concerns the gene STIM1 and cancer.