CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome: Interestingly, the estimated cumulative risk for LBC in CDH1 mutation female carriers is 39% (95%CI, 12–84%) while the combined risk of gastric cancer and breast cancer in women rises to 90% by age 80 years, indicating that family history of multiple LBCs at a young age should encourage genetic screening for CDH1 mutations [11].