In detail, considering antibodies pattern of SSc patients, a significant correlation between ANA and PI3K expression (p = 0.044) and between ANA and PDGFRβ (p = 0.031) was observed, with a trend towards significance regarding to ACA and PDGFRβ (p = 0.074) and ANoA and PI3K (p = 0.079). This evidence concerns the gene FDXR and systemic sclerosis.