Moreover, upregulation of 9 of the 50 genes, including COL16A1, EMILIN1, CLMP, COL6A2, CCDC80, FMNL3, PCDHGB7, COL6A3, COL8A2, strongly support the idea that accumulation of collagenous and ECM glycoproteins in the GC microenvironment may strongly affect the progression of the tumor and ultimately impact on its metastatic behavior. This evidence concerns the gene COL8A2 and neoplasm.