The role of 28 of the 50 genes upregulated in CDH1-mutated cases, including COL16A1, OMD, S1PR2, CLMP, KCNE4, CCDC80, FMNL3, VSTM4, PCDHGB7, CILP, POU2AF1, SERPINF1, GGT5, THBS4, GLIPR2, COL8AT2, RFRAT2, RFRAT2 GLT8D2, MAP1A, FBLN2, BOC, LSP1, PLEKHO2, TMEM273, OLFML1, SC5D, and NDN, remains unresolved in the context of GC. The gene discussed is SERPINF1; the disease is gastric cancer.