Bioinformatic analysis for gene expression profiles of 2447 glioma samples demonstrated that IGFBP2 has immunosuppressive activities in glioblastoma (GBM), and IGFBP2 is positively correlated with immunosuppressive molecules’ expression, including VEGFA, CHI3L1, ANXA1, TNFRSF1A, LGALS3, TIMP1 and LGALS1 [37]. Here, ANXA1 is linked to central nervous system cancer.