Regarding RA, AMPK activation inhibits several inflammatory pathways, which include Janus kinase/signal transducer and transcription activator (JAK/STAT), PI3K/Akt, sirtuin 1 (SIRT1), NFB, and the cAMP response element binding protein pathways (CREB) [75]. The gene discussed is AKT1; the disease is rheumatoid arthritis.