NOTCH1 and central nervous system cancer: Interestingly, a combined study on NOTCH gene mutations in glioma and GBM and patient’s survival (data obtained from cBioPortal) highlighted that the patient’s survival was lower in patients with NOTCH4 mutations (11 months) and NOTCH3 (13 months) compared to NOTCH1 (77 months) and NOTCH2 (19 months).