In addition, two putative haplotypes, HLA-DR3 (HLA-DRB1*0301/-DQB1*0201) and HLA-DR2 (HLA-DRB1*1501/DQB1*0601), were found to be linked to SLE Jordanian patients and LN when compared to healthy controls, while DRB1*0403/DQB1*0302, DRB1*0701/DQB1*0201 and DRB1*1301/DQB1*0603 may be considered protective haplotypes. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.