The amino acid locations 11, 13, 26 and 37 on the epitope-binding cleft of HLA-DRB1, the amino acid location 37 of the HLA-DQB1 and the locations 70 and 9 in HLA-A and HLA-B, respectively, were found to be responsible for HLA-SLE association [11,12]. Here, HLA-B is linked to systemic lupus erythematosus.