HLA-DRB1*0301 (p = 0.005, OR=2.60), HLA-DRB1*1101 (p = 0.041, OR = 1.86) and HLA-DRB1*1102 (p = 0.02, OR = 2.64) showed a positive association with SLE, with a higher frequency of the alleles in the SLE patients’ group in comparison to the control group. The gene discussed is HLA-DRB1; the disease is systemic lupus erythematosus.