Nevertheless, a study performed in the Italian population showed that DRB1*1501 significantly increased the likelihood of developing LN in combination with the DQA1*0101 allele (HLA-DRB1*1501-DQA1*0101), while DQA1*0102 significantly reduced the nephritogenic effects of DRB1*1501 (HLA-DRB1*1501-DQA1*0102) in Italian SLE patients [35]. This evidence concerns the gene HLA-DRB1 and lobular neoplasia.