The results showed that the HLA-DRB1*0301 (p = 0.006, OR = 2.89), DRB1*1101 (p = 0.040, OR = 2.06) and DRB1*1501 (p = 0.043, OR = 2.27) alleles show a positive association with the SLE with LN group, with a higher allele frequency in the LN group in comparison to the control group. This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.