For instance, recently, Sjøgren et al., using screening tests for auto-Abs against IFN-ω and interleukin-22 (IL-22) on a large cohort of patients with endocrine diseases, followed by subsequent genetic testing of positive samples, identified patients with undiagnosed APS-1 as well as several patients with previously unknown monogenic or oligogenic causes of organ-specific autoimmunity and immunodeficiency [15]. Here, IL22 is linked to immunodeficiency disease.