The MetaCore analysis of lung cancer patients also suggested that PTPN3 signaling was correlated with “Cell adhesion_Tight junctions”, PTPN5 signaling was correlated with “Development_Transcriptional regulation of megakaryopoiesis”, PTPN6 signaling was correlated with “Development_Transcriptional regulation of megakaryopoiesis”, PTPN13 signaling was correlated with “Immune response_HMGB1 release from the cell”, and PTPN21 signaling was correlated with “Signal transduction_IGF-1 receptor signaling pathway”. This evidence concerns the gene HMGB1 and lung cancer.