IL10 and cancer: Cancers were often featured with neutrophilia, and elevated neutrophils helped the construction of a tumor microenvironment through the secretion of some essential cytokines, such as vascular endothelial growth factor (VEGF) [36], interleukin- 6 (IL-6) [37], IL-8 [38], IL-10 [8], prostaglandin [39], matrix metalloproteinases [40], among others.