PKP2 and arrhythmogenic right ventricular cardiomyopathy: Although it has been shown in previous studies that early truncation of the PKP2 C-terminus likely causes ARVC irrespective of transcript position [12], desmosomal and non-desmosomal variants can create a certain genetic potential for the development of ARVC, but exercise has an important role in determining the development, severity, and pattern of phenotypic expression.