BRCA1 and breast cancer: In particular, the lifetime risk of breast cancer (BC), for BRCA 1–2 mutations carriers is 40–85% by the age 70 [1,2,3,4]; whereas the risk of ovarian cancer (OC) (including fallopian tube cancer and primary peritoneal cancer) for BRCA1 mutation is 39–46% by the age 70 and for a BRCA2 mutation is 10–27% by the age 70 [1,5,6].