Inactivation mutations in DAXX/ATRX and MEN1 are known to be exclusively found in pNET, and other mutations in the PI3K/mTOR signaling pathway, such as phosphatase and tensin homolog [PTEN], DEPDC5, and PIK3CA, are found in WD-pNET [4,16,17]. This evidence concerns the gene PIK3CA and Wilson disease.