Moreover, the IL17A gene variant has been linked to an increased risk of colorectal cancer in Asians and Caucasians [86,87], osteoarthritis in Caucasians [88], IgA nephropathy in Chinese Hans [89], polycystic ovarian syndrome in Chinese people [90], diabetic nephropathy in Iranians [91], diverse cancer in Asians [92], preeclampsia in Chinese people [93], and rheumatoid arthritis in Europeans [94]. This evidence concerns the gene IL17A and rheumatoid arthritis.