Taking into account the recommendations of the World Health Organization (WHO) [25], the ESMO [16], the British Committee for Standards in Hematology (BSH) [45,46], the European Association for the Study of the Liver (EASL) [47], and the Royal College of Pathologists of Australasia [48], we distinguished groups of CrO patients with different values of serum ferritin, transferrin saturation (TSAT), and hemoglobin in order to identify patients with anemia and various disorders of iron metabolism (Figure 1). The gene discussed is TF; the disease is anemia.