Hypokalemia can be exacerbated by diuretics use [3], leading to lethal ventricular arrhythmias [4], whereas hyperkalemia often leads to withholding prescriptions or up-titration of optimal medical therapy, such as mineralocorticoid receptor antagonists (MRA) and renin–angiotensin system inhibitors (RAS-I), both of which can induce hyperkalemia [5]. Here, NR3C2 is linked to Hyperkalemia.