In food allergy antigen presenting cells (APCs), mainly DC, they activate T naïve cells differentiation into T helper cell 2 (Th2), which induces B-cells-specific IgE (sIgE) production to food antigen and, through proinflammatory cytokines, activates eosinophils, mast cells and basophils responsible for allergy symptoms [17]. This evidence concerns the gene IGHE and allergic disease.