IGHE and allergic disease: Antigen food-specific IgE binds to the FcεRI receptors on mast cells and basophils and degranulates mediators, such as histamine, tryptase, platelet activating factor, prostaglandins and leukotrienes, that cause typical allergy symptoms, such as rash, pruritus, edema, bronchoconstriction and vasodilation [1,15].