Considering the special group showing the extreme discrepancy we found (normal CRP and PCT, but high IL-6, and not low frequency of 1.4% in a large dataset), there would be some cases in which infection or inflammation may be incorrectly determined or may not be detected very early following admission, even with a combination test of CRP and PCT, because IL-6 is a less frequently used biomarker in current clinical settings. Here, CRP is linked to infection.