Although PCT had been considered to have promising tools for early diagnosis of infection, which has better specificity and negative predictive value (NPV) than CRP [16,17,18], it is now clear that the diagnostic power of PCT in adults is limited except its role in guiding antibiotic stewardship (discontinuation rather than initiation) [18,19,20,21,22,23,24]. The gene discussed is CRP; the disease is infection.