TP53 and head and neck squamous cell carcinoma: An analysis of 510 patients with HNSCC (http://gdac.broadinstitute.org/, accessed on 20 August 2022) identified an overall TP53-mutation rate of 70.4%, with higher frequencies in tumors of the larynx and hypopharynx (83.5%) and the tongue and oral cavity (75.6%), but much lower frequency in tumors of the oropharynx (28.6%), which tend to be associated with HPV [43].