IL6 and penile cancer: On the contrary, since the occurrence of micro-incontinence in PC was neither associated with NFKB1/2 nor cytokine profiles (IL-1A, IL-6, INF-γ, IL-1RN, TGFβ and IL-1B; data not published), it seems that the influence of the irritating effect of urine does not play central role in the development of penis cancer as observed in PLS.