Other overlapping pathways between the rat DMRs (current study) and proteomics dataset [19] include cardiac muscle contraction, hypertrophic cardiomyopathy, adrenergic signaling in cardiomyocytes and longevity regulating pathway (DMRs at 1.5 months), as well as gonadotropin releasing hormone (GnRH) secretion, dopaminergic synapse, tight junction and circadian entrainment (DMRs at 7 months). This evidence concerns the gene GNRH1 and hypertrophic cardiomyopathy.