GPC3 and hepatocellular carcinoma: Regarding early diagnosis, three EV subpopulations, EpCAM+ CD63+, CD147+ CD63+, and GPC3+ CD63+ were highly associated with the early diagnosis of HCC (AUROC of 0.95 (95% CI = 0.90–0.99) with a sensitivity of 91% and a specificity of 90%) [77].