Recently, Povero et al. [33] analyzed hepatocyte-derived EVs from pre-cirrhotic and cirrhotic NASH patients, using asialoglycoprotein receptor 1 (ASGPR1) and long-chain fatty acid transport protein 5 (FATP-5) as hepatocyte markers. This evidence concerns the gene ASGR1 and metabolic dysfunction-associated steatohepatitis.