Annexin V+ EpCAM+ CD147+ taMPs were elevated in liver cancer (HCC and CCA).Annexin V+ EpCAM+ ASGPR1+ taMPs were increased in liver cancer compared to patients with cirrhosis. Annexin V+ EpCAM+ ASGPR1+ CD133+ taMPs allowed the distinction of liver malignancies. Here, EPCAM is linked to hepatocellular carcinoma.