Another study used ASGR2 (asialoglycoprotein receptor 2) and CYP2E1 (cytochrome P450 2E1) antibodies as markers of hepatocyte-derived EVs and observed a decrease in ASGR2+ and CYP2E1+ MVs levels after bariatric surgery in 28 biopsy-proven NAFLD patients [8]. Here, CYP2E1 is linked to metabolic dysfunction-associated steatotic liver disease.