A complex technique integrating covalent chemistry-mediated EV capture/release, multimarker antibody cocktails, nanostructured substrates, and microfluidic chaotic mixers showed that purified EpCAM, ASGPR1, and CD147 EVs have a 10-gene HCC-specific signature that allows one to distinguish HCC patients from at-risk cirrhotic patients (AUROC: 0.93 (95% CI, 0.86–1.00; S: 94.4% and S: 88.5%)) [78]. Here, BSG is linked to hepatocellular carcinoma.