The best predictive capability was observed for CRP (AUC 0.806 [0.734–0.878]); fibrinogen, D-dimer and uPAR serum levels showed comparable performances (AUC 0.76 [0.68–0.84], AUC 0.756 [0.677–0.835], AUC 0.738 [0.651–0.825]) in predicting COVID-19-related lung damage severity. Here, PLAUR is linked to COVID-19.