Angiotensin-converting enzyme (ACE), a central component of the renin-angiotensin system, and its insertion/deletion (I/D) gene polymorphism have been linked to hypertension [26], increased cardiovascular risk [27,28], obesity [29] and diabetes [30], all comorbidities strongly associated with adverse COVID-19 outcome. The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.