CD274 and hepatocellular carcinoma: Today, immunotherapies such as immune-checkpoint inhibitors are revolutionizing the management of HCC, and the combination of an anti-PD-L1 (atezolizumab) plus an anti-VEGFA (bevacizumab) and an anti-PD-L1 (durvalumab) plus an anti-CTLA4 (tremelilumab) have shown superior efficacy compared to sorafenib in advanced-stage patients.