In this study, we carried out an evaluation of the effect of novel allosteric AKT inhibitor vevorisertib as a single agent and in combination with sorafenib on HCC in a cirrhotic rat model to define its anti-tumor activity and the safety in an animal model that reproduces the key features of human HCC, including fibrosis/cirrhosis [17]. Here, AKT1 is linked to Cirrhosis.