Particularly, CD163+ TAMs have been observed to secrete IL-6, which, upon binding of IL-6 receptor (IL6R) on the cancer cell surface, phosphorylate STAT3 (pSTAT3) that translocated to the nucleus and regulates the expression of varying microRNAs, including miR-506-3p, which promotes EMT (Figure 3A). The gene discussed is IL6; the disease is cancer.