In such scenario, flourishing literature demonstrated that in response to signals released from cancer cells, adaptive immune cells, B cells, fibroblasts, and macrophages themselves, such as IL-10, CCL2/3/4/5/7/8 and CXCL12 (colony stimulus factor 1 (CSF-1)), VEGF and interleukin-6 (IL-6), monocytes are recruited in the tumor niche and differentiate into the TAMs with an M2-like phenotype [118]. This evidence concerns the gene IL6 and cancer.