In our narrative review, we conducted “a comprehensive PubMed search to find studies assessed the role of inflammation in PD and potential NURR1 involvement that were published in English using the title and abstract MeSH search (((Parkinson’s disease) OR (PD)) AND ((NURR1) OR (NR2A2))) AND (Neuroinflammation)/((Parkinson disease) OR (PD)) AND (Neuroinflammation), after that, a full-text read of the closely related articles. Here, HNF4G is linked to Parkinson disease.