In our narrative review, we conducted “a comprehensive PubMed search to find studies assessed the role of inflammation in PD and potential NURR1 involvement that were published in English using the title and abstract MeSH search (((Parkinson’s disease) OR (PD)) AND ((NURR1) OR (NR2A2))) AND (Neuroinflammation)/((Parkinson disease) OR (PD)) AND (Neuroinflammation), after that, a full-text read of the closely related articles. The gene discussed is NR4A2; the disease is Parkinson disease.