Given the deleterious effects that the disorder of the HIF-1α/LCMT1/PP2Ac/tau axis in AD exerts on numerous pathological events, we speculated, investigated, and provided evidence that blockage of HIF-1α or HIF-1α/LCMT1 might provide pharmacological interference for chronic hypoxia-related tau pathology. The gene discussed is HIF1A; the disease is Alzheimer disease.