These multiprotein complexes are formed by different members of nucleotide oligomerization domain (NOD)-like receptor family pyrin domain (NLRP1, NLRP2, NLRP3) and absent in melanoma (AIM), but in varicocele pathogenesis, the NLRP3 inflammasome was shown to play an important role. This evidence concerns the gene NLRP3 and melanoma.