It has been shown [35,36] that LPS-induced ALI is associated with the NF-κB signaling pathway, and in ALI, LPS is specifically recognized by TLR4, which activates the NF-κB signaling pathway to induce the release of multiple inflammatory factors, including TNF-α, IL-1β, and IL-6. The gene discussed is TLR4; the disease is acute respiratory distress syndrome.