Of the 18 variants found in the APOB gene, 11 were previously described as being mainly associated with hypercholesterolemia and hypertriglyceridemia (category Ip (known mutation)), while 7 were only listed in databases, such as Gnomad, with a frequency of less than 0.01 (Category IIp (potential mutation)). The gene discussed is APOB; the disease is Hypercholesterolemia.