IL-1β and IL-18 released by pyroptosis cells are endogenous immune factors that cause fever, stimulate the activation of immune cells, and promote lymphocyte proliferation and the secretion of antibodies, while excessive pyroptosis leads to the uncontrolled release of IL-1β and IL-18, which will lead to a wide range of inflammatory reactions and immune diseases [3]. Here, IL18 is linked to immune system disorder.