PCDH8 and neoplasm: In the present study, we analyze the same set of genes, particularly ZNF677, PCDH8, FLRT2, FBN2, TAC1, and TFAP2B, in the urine samples of patients diagnosed with SRMs and treated by AS, aiming at the evaluation of their suitability for the extremely early detection of SRMs and tumor growth prediction during the monitoring of the disease.