Interestingly, B7-H3 expression in NSCLC seems to be correlated with low PD-L1 expression and with a poor prognosis in EGFR mutant patients, leading to speculation about an alternative biological pathway and suggesting a role for B7-H3 as an ICI in NSCLC patients [7,9,10]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.