Analogous supportive evidence for interrelations between lncRNAs and enzymes of the epigenetic machinery derives from the long intergenic noncoding antisense RNA (HOTAIR), which preserves Homeobox A1 (HOAX1) gene’s methylation levels through induction of the evolutionarily conserved SET-domain-containing histone methyltransferase EZH2, the DNMT1 and DNTM3B in lung cancer [75,76]. The gene discussed is EZH2; the disease is lung cancer.