DNMT3B and myelodysplastic syndrome: Finally, upregulation of H19-lncRNA has been associated with adverse prognosis in MDS patients [86] and has been interconnected with DNMT3B function in breast cancer [87] by promoting reactivation of BECN1 gene, a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes, playing multiple roles in autophagy, also involved in MDS pathogenesis [88].