Interestingly, HOXB-AS3-lncRNA, transcribed from the human HOXB cluster, is shown to recruit EZH2 to Dicer endoribonuclease’s promoter, an enzyme that cleaves double-stranded RNA and hairpins of the pre-micro and siRNAs [83], and also to be implicated in myeloid cell proliferation with adverse prognosis in AML and MDS [15]. This evidence concerns the gene EZH2 and acute myeloid leukemia.