TNF-α, a pleiotropic cytokine produced mainly by activated macrophages, T lymphocytes, and natural killer (NK) cells, but also by tumor cells themselves, is one of the common and important components of the tumor microenvironment known to promote tumor cell migration and invasion through activation of NFκB and ERK/MAPK signaling pathways [8,34,35]. This evidence concerns the gene NFKB1 and neoplasm.