TUG1 and obesity due to melanocortin 4 receptor deficiency: In another study from this research group, they revealed that TUG1 was significantly downregulated in the adipose tissues from diabetic mice, and the injection of TUG1 overexpression lentivirus via the tail vein significantly attenuated obesity and serum glucose levels, and ameliorated the accumulation of testicular adipose tissue in diabetic mice.