Mechanistically, GAS5 promotes the development of NAFLD by acting as a sponge for miR-29a-3p to enhance the expression of NOTCH2 [34], which promotes lipogenesis in hepatocytes and its deregulation is related to disordered lipid metabolism in women with obesity and NAFLD [120]. Here, NOTCH2 is linked to metabolic dysfunction-associated steatotic liver disease.