Consistent with the study of Xie et al., Feng et al. reported that inhibition of Blnc1 could reduce the fibrosis, inflammation and oxidative stress in high glucose-induced HK-2 cells, and Blnc1 promoted inflammation, oxidative stress and renal fibrosis by activating the Nrf2/HO-1 and NF-κB pathways in diabetic nephropathy [199]. This evidence concerns the gene PAQR9 and diabetic kidney disease.