EPO and glaucoma: An experiment involving an intraperitoneal injection of sustained release EPO-loaded poly lactic-co-glycolic acid/poly lactic acid (PLGA/PLA) microspheres in optic nerve crush rats was carried out by Rong et al. A single injection of EPO-loaded microspheres significantly prevented RGC death from neurodegenerative central nervous system diseases, such as glaucoma, with the same effectiveness as multiple injections of EPO [54].