BHLHE41 and renal fibrosis: In addition, the upregulation of miR-16 has been shown to inhibit inflammation-induced renal fibrosis and glomerular damage and to inhibit the activation of the TLR4 signaling pathway by targeting differential expression 2 (DEC2), thereby inhibiting renal tissue hyperplasia and mesangial cell proliferation, and alleviating the pathological symptoms of renal fibrosis [53].